Endocrine Abstracts

Estradiol (E2) may directly interact with growth factors stimulating cell proliferation and differentiation. Previously, we have demonstrated that E2 through membrane estrogen receptor α (mERα) modulates the lactotroph cell population which exhibit noticeable changes in the pituitary gland. The aim of this study was to analyze the mERα contribution on lactotroph cell proliferation in response to E2 and FGF-2 interaction evaluatin...

Introduction: Bone metastases (BM) are rare in differentiated thyroid cancer (DTC). They determine the quality of life and survival of these patients. Our objective was to evaluate the characteristics, survival and prognostic factors of a cohort of patients with BM from CDT.Methods: Retrospective descriptive study. Patients with BM from DTC diagnosed between 1980-2021 were included. Qualitative variables are shown as n(%); quantitative variables as media...

Introduction: The widespread use of highly-active antiretroviral therapy (HAART) has drastically improved the life expectancy of patients with human immunodeficiency virus (HIV) infection. However, many of these drugs show multiple interactions with other treatments; protease inhibitors (PI) are especially troublesome as they interact with the hepatic cytochrome P450. There have been previous reports of both Cushing’s syndrome and adrenal insufficiency in patients treated...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Introduction: Hypothyroidism is the most frequent thyroid disorder in patients with systemic lupus erythematosus (SLE) but the cause of this association is not well established. Moreover, no studies focused on the possible relationship between some specific immunologic patterns of SLE and the development of hypothyroidism have been reported.Methods: In our study, we determined the immunological features and the thyroid status of 103 consecutive patients ...

Background: Vitamin D deficiency is an important public health problem because of its great impact on bone metabolism and the possible implication in cardiovascular outcomes, diabetes, cancer and mortality. Cross-sectional studies have related vitamin D deficiency with the prevalence of diabetes but there are only a few prospective cohort studies on the incidence of type 2 diabetes.Objective: To investigate the relationship between levels of 25-hydroxyvi...

Higher serum TSH has been recently postulated as a predictor of thyroid malignancy in nodular thyroid disease. In addition, some reports have demonstrated its association with more advanced stages of differentiated thyroid cancer (DTC).Material and methods: We collected retrospectively preoperative serum TSH from patients who underwent total thyroidectomy in the period 2005–2011 in a single tertiary center. We recorded demographic data, nodule numbe...

Bilateral cervical exploration has been the gold standard in parathyroid surgery. Nowadays, the preoperative localization procedures have facilitated the minimally invasive surgery. This study aims to analyze the influence of thyroid disease in Tc99m-sestamibi scintigraphy (MIBI) results.A series of 154 patients with PHP who underwent parathyroidectomy was reviewed. Patients were divided into two groups: group 1 (G1, 58 patients) with thyroid diseases, a...

Background: The indication of ablation with I131 in low-risk DTC is controversial. The exact dose needed for thyroid remnant ablation is still a matter of debate in low-risk DTC patients. However, low dose has been found to be equally effective as high dose in terms of recurrence rate in recent studies. Taking this into account the current trend is to administer lower doses, although some studies describe a higher rate of retreatment.Aims: 1. To examine ...

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...